Genetic makeup also influences body weight response to exercise. Some exercises are simply less likely to produce weight loss in individuals with certain genetic variants. DNA fitness testing allows for a fitness plan that prioritizes the exercises most likely to produce the greatest benefit, whether for improved physical performance or for weight loss Other genetic links that have been discovered include gene variants that cause structural differences in the musculoskeletal system (which includes tendons, ligaments, and joints) and gene variants that impact the ability of muscles to extract and deliver oxygen.

Structural differences affect physical performance and predisposition toward injury, while oxygen consumption rates impact endurance.
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